Kural - 370

Drive from thy soul desire insatiate;
Straight'way is gained the moveless blissful state

Explanation
The removal of desire, whose nature it is never to be satisfied, will immediately confer a nature that can never be changed.

Tamil Transliteration
Aaraa Iyarkai Avaaneeppin Annilaiye
Peraa Iyarkai Tharum.